Diagnostic Accuracy of Indocyanine Green Clearance Test for Different Stages of Liver Fibrosis and Cirrhosis

(1) Background: This study aimed to correlate the indocyanine green clearance (ICG) test with histopathological grades of liver fibrosis and cirrhosis assess its diagnostic accuracy in differentiating normal parenchyma from cirrhosis. (2) Methods: A total 82 patients who received a examination, imaging, ICG within three months were included this retrospective study. The level was graded using Ishak scoring system, divided into five categories: no (NLF), mild (MLF), advanced (ALF), severe (SLF), (LC). non-parametric Kruskal–Wallis post hoc pairwise comparison utilizing Mann–Whitney U tests Bonferroni adjustment used analyze differences results between patient groups. Cross correlation individual fibrosis/cirrhosis stages score performed, sensitivity, specificity, positive negative predictive values calculated for each model predicting fibrosis/cirrhosis. (3) Results: significant difference (p ≤ 0.001) NLF, LF, LC found parameters (ICG plasma disappearance rate (ICG-PDR) retention percentage at 15 min (ICG-R15)). analysis revealed that NLF significantly differed SLF (ICG-PDR: p = 0.001; ICG-R15: 0.001). ALF also 0.033; 0.034) 0.014; 0.014). sensitivity detection an initial stage compared (Ishak ≥ 1) 0.40; corresponding specificity 0.80. differentiation or 4) other 0.75, 0.81. (4) Conclusions: shows test, as non-invasive is able differentiate seems be helpful monitoring regarding compensation levels, thus potentially enabling physicians both detect progression compensated initiate antifibrotic treatment earlier stage.